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This ginger derivative appeared to exert its effects by inhibition of proliferation, induction of apoptosis, and suppression of NF-κB and heme oxygenase expression in both colon and lung cancer tissues ().

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Initially, 30 or 60 mg once daily.

The manufacturer recommends pregnancy be excluded in female patients two weeks prior to commencement of isotretinoin, and they should use two simultaneous forms of effective contraception at least one month prior to commencement, during, and for at least one month following isotretinoin therapy.

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In chronic stable angina (effort-associated angina), nifedipine has been effective in controlled trials of up to eight weeks duration in reducing angina frequency and increasing exercise tolerance, but confirmation of sustained effectiveness and evaluation of long-term safety in these patients is incomplete.

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Drug Interactions: Beta-adrenergic blocking agents: (See and ) Experience in over 1400 patients with nifedipine capsules in a noncomparative clinical trial has shown that concomitant administration of nifedipine and beta-blocking agents is usually well tolerated, but there have been occasional literature reports suggesting that the combination may increase the likelihood of congestive heart failure, severe hypotension, or exacerbation of angina.

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Scientists involved in the clinical trials published articles warning of birth defects at the same time the drug was launched in the US, but nonetheless isotretinoin was taken up quickly and widely, both among dermatologists and general practitioners.

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Zidek W, Spiecker C, Knaup G, Steindl L, Breuer HWM "Comparison of the efficacy and safety of nifedipine coat-core versus amlodipine in the treatment of patients with mild-to-moderate essential hypertension.

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Patients with strong motivation to prevent all future stones, those with multiple recurrences or single functioning kidneys, and all children younger than 16 years with nephrolithiasis should be referred to a specialist in nephrolithiasis prevention.

The nifedipine gastrointestinal therapeutic system in the treatment of hypertension.

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When the GITS formulation was compared to prolonged action and capsule formulations nifedipine GITS was better tolerated with respect to overall adverse events, particularly headache and dizziness ().

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