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Excessive acid secretion, inflammation of the stomach or duodenum, food allergies, lifestyle and diet influences, psychological factors, medication side effects (from drugs such as non-steroidal anti-inflammatory drugs and aspirin), and Helicobacter pylori infection have all had their proponents.
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It is used to treat gastroesophageal reflux disease (GERD), certain ulcers, inflammation of the esophagus, and Zollinger-Ellison Syndrome.
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All subjects should be judged normal and healthy during a pre-study medical evaluation (physical examination, laboratory evaluation, 12-lead ECG, hepatitis B and hepatitis C tests, HIV test, and urine drug screen including amphetamine, barbiturates, benzodiazepine, cannabinoid, cocaine, opiates, phencyclidine, and methadone) performed within 14 days of the initial dose of study medication.
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PPIs included in the study were omeprazole (ATC: A02BC01), pantoprazole (A02BC02), lansoprazole (A02BC03), rabeprazole (A02BC04) and esomeprazole (A02BC05).
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In the partial-onset seizures clinical trials, hostility- and aggression-related adverse reactions occurred in 12% and 20% of patients randomized to receive FYCOMPA at doses of 8 mg and 12 mg per day, respectively, compared to 6% of patients in the placebo group.
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In some patients with high-risk disease, a step-down approach with early introduction of stronger agents such as the anti-TNF agents has been advocated to prevent complications and improve patient outcomes.
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This approach suggests that using high-dose oral PPIs twice-daily may overcome the risk of rebleeding owing to the prolonged effective acid suppression of oral formulations.
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Arthrotec is a combination of an ulcer-protective drug called misoprostol and the NSAID diclofenac.
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